ࡱ> _ 1bjbj B6r=\r=\AI  8\>LK(bJdJdJdJdJdJdJ$LOJ9JJs s s RbJs bJs s -.PƇrR,.NJJ0K@.#PG#P(..n#P.1 s JJK#P > \: QUEENS UNIVERSITY BELFAST RISK ASSESSMENT FOR AN ACTIVITY INVOLVING GENETICALLY MODIFIED MICROORGANISMS Section 1 Project or Activity 1.0 Title of project  Principal Investigator(s)/ Researchers 1.2 School/Centre/Research GroupLocation of Work (Building and Room Number)1.4 Project Description 1.5 Scientific Goals This should put the work in context but is not obligatory. Scientific goals need not be disclosed if this compromises intellectual property rights or commercial sensitivity 1.6 Date of Assessment  Section 2 Genetically Modified Micro-organism Constructs 2.1 Overview This should outline the scope of the project and define exactly what work will be performed. Provide details of the organisms being studied including: ACDP category, culture requirements, spore formation, if pathogens the route of transmission and any details relevant to survival out with the laboratory environment. If cloning for the purposes of over expression and generation of recombinant proteins this should be detailed. If knock-out/deletion mutants are being generated ,consideration should be given as to whether this may reduce or enhance virulence  2.2 List of Recipient Strain(s) Include examples of the strains, if applicable, the wild-type organism from which derived and the extent to which it is disabled. Where these are commercially available reference to the source should be made.  2.3 List of Vector(s) Include examples and details of any disabling mutations, whether the vector is mobilisable, non-mobilisable or self-transmissible. Where these are commercially available ,reference to the source should be made  2.4 List of Function of Inserted /deleted/complemented Gene(s) Genes should be identified so that reviewers have a general idea of their function (a 3 letter name may be insufficient) Where gene function is not known please give details of any known homologues. Generic examples may be sufficient.  2.5 Most Hazardous GMM Considering human health and environmental risks, the most hazardous GMM to be constructed in this work should be identified, This will be the most hazardous combination of recipient strain, vector and insert from lists made in 2.1. Where it is not clear that any one GMM is more hazardous than others (i.e. if all are Class I), this should be stated).  2.6 Are there any harmful properties associated with the recipient strain, the vector, or the inserted material? If the answer is yes or you are unsure complete Section 3 YES/NO ` 2.7 Will any of the final GMMs be hazardous to humans or the environment? YES / NO If the answer is yes or you are unsure complete Section 3 2.8 Are you assigning all the work to Containment Level 1? YES / NO If you answered No to 2.6 / 2.7 you may have sufficient information to classify the project to Class1 as defined in the Contained Use Regs (2000). However you should be confident that in the event of a total breach of containment the GMO would be of no/negligible risk to human health or the environment  Background notes It is not appropriate to consider non-disabled pathogens of plants, humans, animals or insects as inherently safe recipient micro-organisms. Examples of inherently safe recipient microorganisms which, depending on the nature of the insert, would in most cases be expected to form the basis of extremely safe GMMs are as follows: (i) E. coli K12 (ii) Defective retrovirus produced from packaging line in which the helper genes are located in two separate blocks of DNA (thus eliminating the possibility of a reversion to replication competence by a single recombination event) and which are self-inactivated to prevent insertional activation. (iii) E1 deleted adenovirus The types of gene which when cloned into particular recipient microorganisms might give rise to a harmful phenotype can be divided into two types. First the gene might encode a product that could act directly to cause harmful effects e.g. a toxin gene or a cytokine. Second the gene might encode a product that could act alongside the existing characteristics of the recipient microorganism so as to endow the GMM with altered pathogenic properties e.g. a pathogenicity gene or an engineered viral envelope gene with an altered receptor binding capacity. Section 3 Continuation Form Required Where Detailed Risk Assessment Necessary 3.1: Identification of Hazards to Human Health arising from:(a)Recipient Microorganism Is the microorganism listed in ACDP hazard groups 2, 3 or 4? What is its mode of transmission, host range, tissue tropism? Are vaccines/chemotherapeutic agents available? Are there any disabling mutations and can they be complemented/reverted?  YES / NO (b) Inserted Gene Product Does the insert encode a toxin, oncogenic protein, allergen, growth or differentiation modulator (hormone/cytokine) or any other protein which may result in potentially harmful biological activity? Where gene function is unknown please describe the function of known homologues. Over expression of normal human genes may be harmful especially in tissues not normally expressing the protein  YES / NO (c) Alteration of Existing Traits Does the gene insert encode a pathogenicity determinant (e.g. adhesin), a penetration factor or surface component conferring resistance to host defence mechanisms? Does the gene insert encode a surface component/envelope or capsid protein which might bind to a different receptor to that used by the recipient microorganism? Does the insert (or plasmid sequence) encode resistance to drugs/antibiotics used for the treatment of laboratory acquired infection?  YES / NO (d) Transfer of GMM sequences Is widespread dissemination of the gene insert (as a result of gene transfer/recombination of the GMM with a WT microorganism) a matter of concern? If so, and in the event of a breach of containment could the GMM survive in the environment long enough for such a gene transfer to occur?  YES / NO 3.2: Assignment of Provisional Containment LevelContainment level (CL 1) ( Containment level (CL 2) ( Containment level (CL 3) (Select oneConsider the containment level necessary to control the risk of the microorganism (i.e. ACDP Hazard Group of the recipient microorganism) and determine if the modification will result in a GMM which is more/less/equally hazardous. 3.3: Identification of Hazards to the Environment(a) Recipient Microorganism Is the recipient microorganism capable of infecting plants/animals/insects in the environment? Could disabling mutations be complemented / reverted? Is the recipient microorganism a DEFRA / DARD controlled pathogen?  YES / NO (b) Inserted Gene Product Does the sequence encode an insect/animal toxin or a product which can cause silencing of a gene encoding a crucial metabolic enzyme in susceptible hosts? YES / NO (c) Alteration of Existing Traits Does the gene insert encode a pathogenicity determinant (e.g. adhesin), a penetration factor or surface component conferring resistance to host defence mechanisms? Does the gene insert encode a surface component/envelope or capsid protein which might bind to a different receptor to that used by the recipient microorganism? YES / NO (d) Transfer of GMM sequences Is wide spread dissemination of the gene insert (as a result of gene transfer/recombination of the GMM with a WT microorganism) a matter of concern? If so, and in the event of a breach of containment could the GMM survive in the environment long enough for such a gene transfer to occur?  YES / NO  Section 4 Nature of Work and Controls 4.1: Generation of AerosolsAre any work procedures likely to generate aerosols? YES / NO If yes should the work be undertaken in a safety cabinet or isolator? 4.2: Microbiological Safety cabinets (MSC)Class 1 % Class 2 % Class 3 ( Other (Select all that apply 4.3: Sterilisation, Disinfection, Inactivation and Waste Disposal How will waste materials be disposed of? Consider waste streams for solid/liquid laboratory waste and waste from infected animals Consult QUB Waste Disposal Procedure ED/S/24/2008 provide details of disinfectant and concentrations. Note that autoclaving should be used to dispose of all GMM waste even for projects assessed at containment level 1. Disinfection ( Autoclave ( Fumigation ( Incineration ( Other ( 4.4: Validation of Disinfectants under Actual Conditions of UseHas the disinfectant been validated under the conditions of use? YES / NO e.g., if being used for treatment of virus in cell culture medium is the disinfectant effective in the presence of high levels of viral protein? 4.5: Use of SharpsWill sharps be used? YES / NO 4.5: Storage of Biological Agents or HazardsAre any of the microorganisms Schedule 5 Agents as defined in Part 7 of the Anti-terrorism, Crime and Security Act 2001? YES / NO 4.6: Transport of Biological Agents or HazardsThe GB regulations covering the carriage of dangerous goods by road and rail are derived from European Directives (ADR (road) and RID (rail)), which in turn implement international modal agreements governing the transport of dangerous goods. The GB regulations directly reference ADR in relation to the classification, packaging and labelling of all classes of dangerous goods, including infectious substances, and are updated every two years. Biological agents, or materials that contain or may contain them, are allocated to UN Division 6.2 - infectious substances. Division 6.2 includes biological products, cultures, genetically modified micro-organisms (GMMs) and genetically modified organisms (GMOs) and medical/clinical waste. Are you in compliance with relevant legislation? YES / NO4.7: Shedding of GMMs by Infected AnimalsIf the work involves the experimental infection of animals is it known if the animal will shed the GMM? YES / NO 4.8: Transmission of GMM in Infected PlantsIs the microorganism insect borne or carried in run-off water? YES / NO If yes what additional containment methods are required? 4.9: Complex life-cycles: Particularly Hazardous Life Cycle StageIn the case of organisms whose multiplication involves a complex life-cycle, will the work involve the propagation of organisms that are in stages in that life-cycle that are particularly hazardous? ( e.g. propagation of the infective stages of parasites or release of fungal spores Have you considered all potential routes of transmission? 4.10: Health Surveillance or Immunisation (If you need advice contact the University Occupational Health Service)Will workers receive vaccinations/health surveillance? Should vaccine status be checked / boosted? YES / NO 4.11: Incompatible Medical ConditionsDoes the nature of the work preclude it being undertaken by workers with health problems that might make them more susceptible to infection or risk in pregnancy/breast feeding? YES / NO 4.12: Emergency ProceduresAre sufficient emergency procedures in place and what are they? Specific reference may be made to relevant SOPs and Risk Assessments relating to spills/disinfection / decontamination and copies provided if appropriate. 4.13: Instruction, Training and SupervisionHas sufficient and appropriate training been given to approve workers? YES / NO  Section 5 Additional Measures over and above Provisional Level of Containment 5.1: Additional MeasuresThe containment measures outlined in Part II of Schedule 8 of the Contained Use Regulations will include some measures required where, and to the extent that the risk assessment shows they are required. However additional measures may be in any of the following circumstances: To take full account of any properties of the GMM hazardous to human health To protect the environment To provide additional safeguards for particular work procedures  Section 6 Final Assignment of Containment Measures and Risk Class 6.1: Aspects of the Project assigned to Class 1 6.2: Aspects of the Project assigned to Class 2 6.3: Aspects of the Project assigned to Class 3  Person Making AssessmentName: Position: Signed: Date: Please return completed form to: Dr David Norwood Biological Safety Officer University Safety Service 5a Lennoxvale Belfast BT9 5BY Tel 90974610  HYPERLINK "mailto:d.norwood@qub.ac.uk" d.norwood@qub.ac.uk You will receive a response within 14 days of received application Please note that risk assessments are subject to pre-screening and will be returned without assessment if they fail to provide suitable and sufficient information presented in a professional manner. 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