ࡱ> ] t7bjbjZ!Z! F8K4\8K4\X+Eb b ***>>>8v2>Z( ZZZZZZZ$\n_CZ* ) ^ CZ%XZS%S%S% 8*ZS% ZS%S%9;7g[!!R:" ZnZ0Z;_s!_D;;_*y>S% CZCZ?# Z _ b > : QUEENS UNIVERSITY BELFAST RISK ASSESSMENT FOR AN ACTIVITY INVOLVING GENETICALLY MODIFIED ANIMALS To be completed where a GM (transgenic or knock-out) animal is to be used / produced Notes (1) It is the responsibility of the Principal Investigator (PI) to undertake a risk assessment in relation to any GM animals they, or members of their research group, use or hold irrespective of where the GMO was originally made. The risk assessment should then be reviewed and approved by the Universitys Biological and Infectious Agents Advisory Committee. It is the responsibility of the PI/user to provide a copy of the risk assessment to the BRU Chief Technician and/or NACWO whose responsibility it is to ensure the person responsible for the day to day care of the animals in the holding facility is informed that genetically modified animals are being used along with the relevant health and safety information. (2) In order to undertake the work detailed below the requirements of the Animals (Scientific Procedures) Act 1986 must also be met if the animals are protected under this Act. Where this is the case a Project Licence and Personal Licence will be required. If necessary, investigators should contact either the BRU Chief Technician or Academic Lead for further information. 1. Project or Activity 1.0 Title of project  Principal Investigator(s)/ Researchers 1.2 School/Centre/Research GroupLocation of Work (Building and Room Number)1.4 Project Description 1.5 Scientific Goals This should put the work in context but is not obligatory. Scientific goals need not be disclosed if this compromises intellectual property rights or commercial sensitivity  1.6 Project Licence Number 1.7 Date of Assessment  2. Describe how the Genetically Modified Animal was/will be produced If the genetically modified animal has been / will be infected with a genetically modified micro-organism please attach a copy of the associated risk assessment for production of the modified micro organism  3. Risk Assessment for the Environment a) Identify any hazards to the environment. Consider: capability to survive, establish disseminate, compete or displace other animals; direct adverse effects on animals and plants; potential to transfer genetic material between the GM animals and other organisms; any toxic/biologically active properties of the products of gene expression; phenotypic and genetic stability; any other negative effects. If there are no hazards identified, please state this, and then go to Section 4 b) Where hazards are identified use the risk matrix below to identify the likelihood [H,L,M,N] and consequence[ S,M,L,N] of the hazards being manifested in order to determine risk [H,M, L, EZ] . A key consideration will be whether the application of Standard Animal Containment Measures, as shown at the end of this form, will ensure risk is effectively zero. [Circle/highlight as appropriate] Likelihood of hazard being manifestedConsequence of hazardHigh HMedium MLow LNegligible NSevere S HighHighMediumEffectively zeroMedium M HighMediumMed/LowEZLow L Med/LowLowLowEZNegligible N EZEZEZEZ 4. Containment Measures to Protect Environment: Are standard animal containment measures as detailed below adequate to ensure risk to environment is effectively zero? YES / NO If No please provide details of additional measures required:  5. Risk Assessment for Human Health and Safety Consider any additional hazards to human health, which arise from the genetic modification of the animal over and above that which would be expected from the unmodified parental animal. These might include, novel or increased allergenicity, possible toxic effects from production of toxins/biologically active proteins, adverse behavioural effects e.g. increased aggression, changes to the ability for animal to act as a human disease reservoir] In organisms whose multiplication involves a complex life-cycle consider whether the work will involve the propagation of organisms that are at stages in that life-cycle that are particularly hazardous. If no hazards to humans please state to that effect If hazards are identified and taking account of measures in place to protect environment use the risk matrix below to identify likelihood [H, M, L, N] and consequence [S, M, L, N] and determine risk.[ H, M , L, EZ] [Circle/highlight as appropriate]  Likelihood of hazard being manifestedConsequence of hazardHigh HMedium MLow LNegligible NSevere SHighHighMediumEffectively zeroMedium MHighMediumMed/LowEZLow LMed/LowLowLowEZNegligible NEZEZEZEZ 6. Containment and Control Measures to Protect Human Health & Safety There is no regulatory requirement to set a formal containment level for work with GM animalsnor arenotification requirements determined by containment measures. Notificationwill however be required if the GM animal is considered more harmful to humans that theunmodified organism. 6.1: Is the proposed level of containment to protect the environment sufficient to ensure risk of harm to human health and safety is effectively zero? YES / NO If No please provide details of additional measures required: 6.2: Does the GM Animal pose a greater risk to human health than the unmodified parental strain? YES / NO If Yes this activity must be notified to HSENI 6.3:Health Surveillance or Immunisation (If you need advice contact the University Occupational Health Service)Will workers receive vaccinations/health surveillance? Should vaccine status be checked / boosted? YES / NO 6.4:Incompatible Medical ConditionsDoes the nature of the work preclude it being undertaken by workers with health problems that might make them more susceptible to infection or risk in pregnancy/breast feeding? YES / NO6.5:Emergency ProceduresAre sufficient emergency procedures in place and what are they? Specific reference may be made to relevant SOPs and Risk Assessments relating to spills/disinfection / decontamination and copies provided if appropriate. 6.6:Instruction, Training and SupervisionHas sufficient and appropriate training been given to approve workers? YES / NO 7. Additional Measures where required 7.0: Additional MeasuresThe containment measures outlined in Part II of Schedule 8 of the Contained Use Regulations will include some measures required where, and to the extent that the risk assessment shows they are required. However additional measures may be in any of the following circumstances: To take full account of any properties of the GMM hazardous to human health To protect the environment To provide additional safeguards for particular work procedures  Person Making AssessmentName: Position: Signed: Date:Please return completed form to: Dr David Norwood Biological Safety Officer University Safety Service 5a Lennoxvale Belfast BT9 5BY Tel 90974610  HYPERLINK "mailto:d.norwood@qub.ac.uk" d.norwood@qub.ac.uk You will receive a response within 14 days of received application All risk assessments that require Class 2 containment or higher must be approved by the HSE (NI). This process may take up to 1 month. Work should not be commenced until this form has been reviewed by BIAACand approved (if necessary) by HSE (NI). Standard Containment Requirements for Genetically Modified /Altered Animals A risk assessment, approved by the relevant GM safety committee, must be provided to the appropriate animal facility manager. The level of risk to both Human Health and the Environment must be effectively zero when the mandatory containment measures outlined below are adopted. If this is not the case, additional measures must be discussed with the relevant facility managers and built into the Risk Assessment. Standard Containment Measures for Rodents: The transgenic animals are housed within a purpose built laboratory animal facility with limited access and appropriate security arrangements in place. Animal holding and procedure areas (including behavioural areas) are protected by appropriate physical barriers, either double 'escape proof' door arrangements or rodent barriers. Where a double door system is used the doors must be kept closed. A high standard of housekeeping is required to prevent concealment of any escaped animals. Animal & procedure rooms will be to Home Office Code of Practice standard. Floor drains (if present) are fitted with a 'drain trap' and are covered to prevent escape. Animals are kept in purposely designed and approved cages/experimental apparatus that will contain the mice and prevent escape. The number of adult animals must be checked weekly by a competent person against the cage record (during the cage change) and whenever the cage is opened and/or animals returned to the cage. Full records of animal stocks are held by the Home Office Project licence Holder Movement of animals around the facility must be done in escape proof cages and for conventional cages, using Scantainers. These must be loaded and unloaded behind the closed doors of the animal holding or procedure area. All experimental procedures must be conducted in a way that minimises the risk of escape. Only manageable numbers of animals should be handled at any one time. In the event of an animal escaping, secure the area and attempt to recapture immediately. If necessary summon help and seal off the area until the animal can be re-captured. Animal traps are available from the facility manager if required. Inform relevant personnel of the escape. A formal record of any un-captured animals must be maintained. All bedding is to be disposed of as per QUB BRU Protocol. All carcases and tissue waste are to be disposed of as clinical waste for incineration. Carcasses, tissues or surplus animals must not be used as feedstuffs for other animals     Page  PAGE 6 of  NUMPAGES \* MERGEFORMAT 6 Please provide the following information: Species and Strain of animal to be modified Techniques by which modification will be accomplished (microinjection/viral vector/transfection of embryonic stem cells) Constructs/Inserts to be used Summarise the nature of the modification (details of the inserted/deleted gene, including known or speculative gene function or effect, how gene is modified and the expression system) Are the products of gene expression harmful in any way? (Can the GM animal act as a novel reservoir for pathogens? If the work involves the experimental infection of animals is it known if the animal will shed the GMM?) What effect is the modification likely to have on the GM animal? (If known, state the effect of mutation/damage/over-expression of the gene in the donor species. For knockouts give expected effect of gene loss. Are there any expected physical or behavioural changes arising from the modification? DE`abc  »tftVtJB; hNohNohDCJaJhNo@OJQJ^Jhl@CJOJQJ^JaJhNoCJOJQJ^JaJhNo@CJOJQJ^JaJ!hNo>*@CJOJQJ^JaJ h#/h-thgCJOJQJ^JaJ h?h?CJOJQJ^JaJ h?h?h?h hE h3h3CJOJQJ^JaJh CJOJQJ^JaJ#huAh{&5CJ OJQJ^JaJ EbcdQQ$ `0vp*$a$gdNonkd$$Ifl))  &0)4 lap & $$Ifa$gd? $Ifgd? $$Ifa$gd? $$Ifa$gd][ # 9 : ; < = > $If   $Ifgd_FgdNogd #*$ `0vp*$a$gdNo$a$gdNo  " # ' , - 1 7 8 : = > ? Y Z e f l qcUDqq h4gh]CJOJQJ^JaJhDCJOJQJ^JaJh<CJOJQJ^JaJh]CJOJQJ^JaJ h4ghS VCJOJQJ^JaJ h4ght6CJOJQJ^JaJh_FCJOJQJ^JaJ h4gh-tCJOJQJ^JaJ h4ghkyCJOJQJ^JaJ h4gh<CJOJQJ^JaJhwnhpCJaJhgCJaJhwnh<CJaJ> ? Z f g h i j k {rlllll$If $Ifgd]  & F$Ifgd]vkd$$Ifl0r f) L04 layt~k l y$If $Ifgd_Fvkd@$$Ifl0r f) L04 layt~ {rl$If $Ifgd]  & F$Ifgd]vkd$$Ifl0r f) L04 layt~ ')㽬|kkSEhx~ICJOJQJ^JaJ.jhx~ICJOJQJU^JaJmHnHu h]56CJOJQJ^JaJ h4gh<CJOJQJ^JaJ h4gh]CJOJQJ^JaJh]CJOJQJ^JaJ h4gh-tCJOJQJ^JaJ#h]h]5CJOJQJ^JaJ&h]h]56CJOJQJ^JaJh]5CJOJQJ^JaJh-tCJOJQJ^JaJ r $Ifgd T $Ifgd<vkd~$$Ifl0r f) L04 layt~ ()|$If$Ifvkd$$Ifl0r f) L04 layt~ Ϳͱ}oaO@1@h'5CJOJQJ^JaJh\ 5CJOJQJ^JaJ#hwnhwn5CJOJQJ^JaJhNoCJOJQJ^JaJhwnCJOJQJ^JaJ# *hN?he'CJOJQJ^JaJ h4ght6CJOJQJ^JaJ h4ghe'CJOJQJ^JaJh]CJOJQJ^JaJhx~ICJOJQJ^JaJ h4gh<CJOJQJ^JaJ h4gh-tCJOJQJ^JaJ h4ghx~ICJOJQJ^JaJy$If $Ifgdx~Ivkd$$Ifl 0r f) L04 layt~e```gdaj U"$d'dNQ]gd9gde'vkd[$$Ifln0r f) L04 layt~  '.Nyʵr`N<#hjh d6CJOJQJ^JaJ#hjh d5CJOJQJ^JaJ#hQ1hQ15CJOJQJ^JaJ#hQ1h7 5CJOJQJ^JaJhNo5CJOJQJ^JaJhb5CJOJQJ^JaJhNohLB hajhajhaj(jh h"xUmHnHsH tHuh dB*phhu^hBqB*phhWTB*phhEB*ph#hwnhe'5CJOJQJ^JaJ     gdaj !"#$%&'NgdajN1yNE< $Ifgdu $IfgdN*T$d%d &d'dNO PQ]TgdmP6$T$d%d &d'd-D M NO PQ]Ta$gd7 T%d 'dO Q]TgdN?6$T$d%d &d'd-D M NO PQ]Ta$gd7 /014Px<=DEnuvɵ}l}[J[J[ hkhjCJOJQJ^JaJ hkh dCJOJQJ^JaJ hjh dCJOJQJ^JaJ h dCJhjh dCJaJhuCJaJ hjCJ h d6CJ#hjh d6CJOJQJ^JaJ&hjh d56CJOJQJ^JaJ#hjh d5CJOJQJ^JaJ#h)MhI56B*CJaJph#h)Mh d56B*CJaJph ')-/:<wwwwwwww $$Ifa$gdN $IfgdNskd$$Ifl8)P#   0*4 lap yt <=QV[bOF::: $$Ifa$gdN $Ifgd<{ikd$$Iflrr8 I) tt 0*4 layt<{ibvwF=11 $$Ifa$gdN $Ifgd<{ikd$$Iflrr8 I) tt 0*4 layt<{i $Ifgdjvw}~±Ž|xfWfHhg5CJOJQJ^JaJh&`5CJOJQJ^JaJ#h+sh+s5CJOJQJ^JaJh d#hNhj5CJOJQJ^JaJ#hNh d5CJOJQJ^JaJ ho/hjCJOJQJ^JaJ ho/h dCJOJQJ^JaJ h dCJhjCJOJQJ^JaJh<{iCJOJQJ^JaJ hjh dCJOJQJ^JaJh+sh d5CJC: $Ifgd<{ikdy$$Iflrr8 I) tt 0*4 layt<{i $$Ifa$gdNC: $Ifgd<{ikdP$$Iflrr8 I) tt 0*4 layt<{i $$Ifa$gdN"C>1 -DM gd dgd dkd' $$Iflrr8 I) tt 0*4 layt<{i $$Ifa$gdN    !"NV6>?{ϽޙކqcqRqRq;,h1uh6B*CJOJQJ^JaJph hhCJOJQJ^JaJh CJOJQJ^JaJhCJOJQJ^JaJ hshh dh&`5CJOJQJ^JaJ#h+sh&`5CJOJQJ^JaJ#h+shg5CJOJQJ^JaJ#h+sh15CJOJQJ^JaJhu5CJOJQJ^JaJhg5CJOJQJ^JaJ#h+sh d5CJOJQJ^JaJ"?}~|sjjj $Ifgd $Ifgd0aykd $$Iflp))  0)4 l` ap yt0a $Ifgd {|~:nop #2EhĵpfYE3E3E3E3#huh d6CJOJQJ^JaJ&huh d56CJOJQJ^JaJh+Nhym6B*phh d6B*ph/h+Nh d56B*CJOJQJ^JaJphhuh d5CJ^JaJhuh dCJ^JaJ#hh5CJOJQJ^JaJhNo5CJOJQJ^JaJ hhCJOJQJ^JaJ,h1uh6B*CJOJQJ^JaJph&h6B*CJOJQJ^JaJpho:NN2$$d%d&d'd-DM NOPQa$gd7 gd dykd $$Iflp))  0)4 l` ap yt0a:nopjkl $IfgdN/$d%d&d'd-D M NOPQgd5d&$d%d&d'dNOPQgd}Jhijklm,.12CDW_`cdjkŰrrcrcrcrcrccrcrchh dOJQJ^JaJhh d5OJQJ^JaJ#huh d5CJOJQJ^JaJ h dCJhuh dCJaJhuhuCJaJ(jhuhuCJUaJmHnHuh<CJaJhhXYdCJaJ&huhu56CJOJQJ^JaJ&huh d56CJOJQJ^JaJ wwwwwwww $$Ifa$gdN $IfgdNskdR $$Ifl)p#  0)4 lap yt  QH<<<< $$Ifa$gdN $Ifgd<{ikd $$Iflr 4)   T 0)4 layt<{i,18@CQH<<<< $$Ifa$gdN $Ifgd<{ikd $$Iflr 4) T0)4 layt<{iCDW_cgjQH<<<< $$Ifa$gdN $Ifgd<{ikd $$Iflr 4) T0)4 layt<{ijkz}QH<<<< $$Ifa$gdN $Ifgd<{ikd$$Iflr 4) T0)4 layt<{ikzʸyyjXjjjj#huh%5CJOJQJ^JaJh<{i5CJOJQJ^JaJh7 5CJOJQJ^JaJ#huh7 5CJOJQJ^JaJhu5CJOJQJ^JaJh&`5CJOJQJ^JaJ#huh d5CJOJQJ^JaJho?"B*phh dB*ph h dCJhh dOJQJ^JaJ hNh dCJOJQJ^JaJQLLLLLC $Ifgd1ugd dkdr$$Iflr 4) T0)4 layt<{i#+,hijklnϻnZnZC5h <CJOJQJ^JaJ,h1uh<6B*CJOJQJ^JaJph&h1u6B*CJOJQJ^JaJph,h1uh1u6B*CJOJQJ^JaJph hh1uCJOJQJ^JaJh1uCJOJQJ^JaJ,hdJh&/<5B*CJOJQJ^JaJph&h d5B*CJOJQJ^JaJph,hdJh d5B*CJOJQJ^JaJph2hdJh d56B*CJOJQJ]^JaJph,jklm||sss $Ifgd1u $Ifgd0aykd@$$Iflp))  0)4 l` ap yt0amn| $Ifgd$ykd$$Iflp))  0)4 l` ap yt0as|||| $Ifgd$ykd$$Iflp))  0)4 l` ap yt^$jrs  NxcN:Nc&h*_hd 5CJOJQJ\^JaJ)h*_hd 56CJOJQJ\^JaJ)h5thd 56CJOJQJ\^JaJ hd 5CJOJQJ\^JaJ&h*hd 5CJOJQJ\^JaJ h|hd CJOJQJ^JaJh@1CJOJQJ^JaJh7 CJOJQJ^JaJ,h^$h^$6B*CJOJQJ^JaJphh <CJOJQJ^JaJ hh <CJOJQJ^JaJ | $Ifgd@1ykd>$$Iflp))  0)4 l` ap yt <  A!B!C!D!|||| $IfgdNykd$$Iflp))  0)4 l` ap yt <  { @!A!C!D!E!G!H!i!j!!""3"5"6"{jXIX>0hjj9hd 5OJQJ^Jhd 5OJQJ^Jhd 6CJOJQJ^JaJ#hhd 6CJOJQJ^JaJ h|hd CJOJQJ^JaJh@1CJOJQJ^JaJh7 CJOJQJ^JaJh*h@1OJQJ^Jhd OJQJ^J#h0hd 6CJOJQJ^JaJ#h|hd 5CJOJQJ^JaJhd 6CJOJQJ^JaJ#hBzhd 6CJOJQJ^JaJh*hd OJQJ^JD!E!i!| $Ifgd@1ykd$$Ifl))  0)4 l` ap yt <i!j!6"7""3#|||s $Ifgd@1 $IfgdNykd<$$Ifl))  0)4 l` ap yt <6"7"""")#*#2#4#6#7#M#N##)$*$+$,$-$.$0$1$X$Y$öwhwZI<h*h<OJQJ^J hDhBCJOJQJ^JaJhd CJOJQJ^JaJhd 6CJOJQJ^JaJ#hDhd 6CJOJQJ^JaJ h|hd CJOJQJ^JaJh@1CJOJQJ^JaJh7 CJOJQJ^JaJh*hd OJQJ^J#h\3hd 5CJOJQJ^JaJh@1OJQJ^Jh<OJQJ^Jhd OJQJ^Jhjj9hd OJQJ^J3#4#M#| $Ifgd@1ykd$$Ifl))  0)4 l` ap yt <M#N#*$+$,$-$|||s $IfgdB $IfgdNykd$$Ifl-))  0)4 l` ap yt <-$.$X$| $Ifgd@1ykd:$$Ifl-))  0)4 l` ap yt <X$Y$$z $H$Ifgd<ykd$$Ifl8))  0)4 l` ap yt <Y$$$$$$$$$$%% %!%9%:%N&O&zl[N<-h-T6CJOJQJ^JaJ#hDh-T6CJOJQJ^JaJh*h-TOJQJ^J h-Th-TCJOJQJ^JaJh7 CJOJQJ^JaJh@bCJaJh-Th-TCJaJh7 CJaJh<CJaJh<h*hcTOJQJ^J#hcTh<6CJOJQJ^JaJ#hh5CJOJQJ^JaJhOJQJ^J hDhCJOJQJ^JaJ#hDh6CJOJQJ^JaJ$$$ %9%|we$-DIfM gdgd-T gd<ykd$$Ifl}))  0)4 l` ap yt <9%:%O&P&&&&&&vvv & F$IfgdN $IfgdNskd8$$Ifl))   0)4 lap yt^_O&&&&&''''(')'8'9'Z'[''''' ( ( ( (O(ΞΞΞΌ~p^p^N^p~<#hoh-T6CJOJQJ^JaJhE<0JCJOJQJ^JaJ#jhE<CJOJQJU^JaJhE<CJOJQJ^JaJh-TCJOJQJ^JaJ#h:<h-T5CJOJQJ^JaJ h4gh-TCJOJQJ^JaJ h-Th-TCJOJQJ^JaJh&/<5B*OJQJphh*h-TOJQJ^J#hh-T6CJOJQJ^JaJ#hDh-T6CJOJQJ^JaJ&&&'{ $IfgdN$a$gd dskd$$Iflq))  0)4 lap yti'''' $Ifgd~skdr$$Ifl))  0)4 lap yt''''(' $IfgdNskd$$Iflq))  0)4 lap yt~(')'1'2'8' $IfgdNskd$$Iflq))  0)4 lap yti8'9'Z'['l''''''' ( (P(Q(||||||||$a$gdE<$a$gd-TskdI$$Iflq))  0)4 lap ytiO(Q(()!)-)=)C)I)J)K)M)))6+˺˩߀lU>- hh dCJOJQJ^JaJ,hh d5B*CJOJQJ^JaJph,hu^h d5B*CJOJQJ^JaJph&hym5B*CJOJQJ^JaJph(hM*h-TCJOJQJ^JaJnH tH &hM*h%6>*CJOJQJ^JaJ h-T6>*CJOJQJ^JaJ hS6>*CJOJQJ^JaJ&hM*h-T6>*CJOJQJ^JaJ hM*h-TCJOJQJ^JaJh-T6CJOJQJ^JaJQ(((J)K)L)M)))7+8+d+++,,P-Q----|.}.<`<gd d & F gd' & F 7$8$gd dgd d$a$gd dk]kgd-T kH$]kgd-T6+8+9+d+ ,,,,..//// 0 000222222223ֿxfTfTfT#h$2hQ5CJOJQJ^JaJ#h$2h d5CJOJQJ^JaJ hh.CJOJQJ^JaJ hhCJOJQJ^JaJ&hh d5>*CJOJQJ^JaJ hh dCJOJQJ^JaJ,hu^h d5B*CJOJQJ^JaJph,hh d5B*CJOJQJ^JaJph#hh d5CJOJQJ^JaJ}.=/>///o0p01h2i222S3T3U3V3W3X3Z3[3]3^3`3a3gdeL(gdzgdb & F 7$8$gdo?" & F gdo?"gd d & F 7$8$gd d3333R3S3T3U3V3W3X3Y3[3\3^3_3a3b3d3n3o3u3v3ۺ~vrvrvrvrgVIVhh$0JOJQJ!jhh$0JOJQJUhh$OJQJh<jh<UhBzOJQJ^JhoOJQJ^JhzOJQJ^Jh*hzOJQJ^J hh& CJOJQJ^JaJ#h$2h d5CJOJQJ^JaJh$25CJOJQJ^JaJ#h$2hQ5CJOJQJ^JaJ#h$2h>I5CJOJQJ^JaJa3c3d3333333333334d4z4{4|4}4~4444gdm & F^gdm & F^gd7gd7  !l(h]hv3w3x3|3}333333333333333333ÿ{i{WI8 h\ hmCJOJQJ^JaJhmCJOJQJ^JaJ#hNhLB5CJOJQJ^JaJ#hNh\ 5CJOJQJ^JaJ#hNhaj5CJOJQJ^JaJ#hEh'85CJOJQJ^JaJ#hEhE5CJOJQJ^JaJhECJOJQJ^JaJh<h$hh$OJQJhh$0JOJQJ!jhh$0JOJQJUhk0JOJQJmHnHu333454{4|4}4~4444455W5X5Y5`5a55C6Ͻ᫜|kYJYJYJ8J#hNh3S5CJOJQJ^JaJh3S6CJOJQJ^JaJ#hbh3S6CJOJQJ^JaJ hbh3SCJOJQJ^JaJ#hNhaj5CJOJQJ^JaJh3SCJOJQJ^JaJh\ 6CJOJQJ^JaJ#hajh%e6CJOJQJ^JaJ#hNhm5CJOJQJ^JaJ#h3Sh3S6CJOJQJ^JaJhm6CJOJQJ^JaJh%e6CJOJQJ^JaJ45Y5Z5[5\5]5^5_5`5a5=6>6?6@6A6B6C6D6m7n7o7p7q7r7 & F^gd%egd7Y^Ygd3Sgd3S & F^gd3SC6D6666666666N7V7m7o7p7q7r7s7t7μuhBzOJQJ^Jh<h dhLB6CJOJQJ^JaJ#hajhLB6CJOJQJ^JaJ h3S6h3S6CJOJQJ^JaJ#h%eh3S6CJOJQJ^JaJ#hmh3S6CJOJQJ^JaJ#hNh3S5CJOJQJ^JaJh3SCJOJQJ^JaJr7s7t7gdeL(DP&P 1/R :p <. A!"#n$n%77 Dp$$If!vh#v):V l  &0)5)/ 4p &$$If!vh#v #vL:V l05 5L/ 4ayt~$$If!vh#v #vL:V l05 5L/ 4ayt~$$If!vh#v #vL:V l05 5L/ 4ayt~$$If!vh#v #vL:V l05 5L/ 4ayt~$$If!vh#v #vL:V l05 5L/ 4ayt~$$If!vh#v #vL:V l 05 5L/ 4ayt~$$If!vh#v #vL:V ln05 5L/ 4ayt~$$If!vh#vP#:V l  0*5P#/  /  4ap yt$$If!vh#v#v#vt#v :V l0*555t5 / /  / / 4ayt<{i$$If!vh#v#v#vt#v :V l0*555t5 / /  / 4ayt<{i$$If!vh#v#v#vt#v :V l0*555t5 / /  / 4ayt<{i$$If!vh#v#v#vt#v :V l0*555t5 / /  / 4ayt<{i$$If!vh#v#v#vt#v :V l0*555t5 / /  / 4ayt<{i$$If!vh#v):V lp  0)5)4` p yt0a$$If!vh#v):V lp  0)5)4` p yt0a$$If!vh#vp#:V l  0)5p#/  / 4p yt$$If!vh#v#v#v#vT:V l0)5555T/ / / /  4yt<{i$$If!vh#v#v#v#vT:V l0)5555T/ /  / / / 4yt<{i$$If!vh#v#v#v#vT:V l0)5555T/ /  / 4yt<{i$$If!vh#v#v#v#vT:V l0)5555T/ /  / 4yt<{i$$If!vh#v#v#v#vT:V l0)5555T/ /  / 4yt<{i$$If!vh#v):V lp  0)5)4` p yt0a$$If!vh#v):V lp  0)5)4` p yt0a$$If!vh#v):V lp  0)5)4` p yt^$$$If!vh#v):V lp  0)5)4` p yt <$$If!vh#v):V lp  0)5)4` p yt <$$If!vh#v):V l  0)5)4` p yt <$$If!vh#v):V l  0)5)4` p yt <$$If!vh#v):V l  0)5)4` p yt <$$If!vh#v):V l-  0)5)4` p yt <$$If!vh#v):V l-  0)5)4` p yt <$$If!vh#v):V l8  0)5)4` p yt <$$If!vh#v):V l}  0)5)4` p yt <$$If!vh#v):V l   0)5)4p yt^_$$If!vh#v):V lq  0)5)4p yti$$If!vh#v):V l  0)5)4p yt$$If!vh#v):V lq  0)5)4p yt~$$If!vh#v):V lq  0)5)4p yti$$If!vh#v):V lq  0)5)4p yti s666666666vvvvvvvvv666666>6666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@_HmH nH sH tH >`> %=Normal7$8$_HmH sH tH R@R  Heading 1$@&5CJ(KHOJQJ\^JaJ(@ ' Heading 2]$$d%d&d'd-D@&M NOPQ56CJOJQJ\^JaJH@H  Heading 3$@&CJOJQJ^JaJZ@Z  d Heading 4$<@&5CJOJPJQJ\^JaJDA`D Default Paragraph FontRi@R  Table Normal4 l4a (k (No List BOB Title head 15CJ\aJ6U`6 Hyperlink >*B*ph44 Header  !4 @"4 Footer  !.)@1. Page NumberFV AF U1FollowedHyperlink >*B* ph.X Q. @Emphasis6]HbH .# Balloon TextCJOJQJ^JaJ@r@ 4g List Paragraph ^R/R  dHeading 4 Char5CJOJPJQJ\^JaJB  d Body TextL$d%d&d'd7$8$NOPQOJQJ</<  dBody Text CharOJQJDP@D  d Body Text 27$8$ 6OJQJD/D  dBody Text 2 Char 6OJQJDQD  d Body Text 37$8$ 5OJQJD/D  dBody Text 3 Char 5OJQJb/b 'Heading 2 Char.56CJOJQJ\^JaJfHq PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭VvnB`2ǃ,!"E3p#9GQd; H xuv 0F[,F᚜K sO'3w #vfSVbsؠyX p5veuw 1z@ l,i!b I jZ2|9L$Z15xl.(zm${d:\@'23œln$^-@^i?D&|#td!6lġB"&63yy@t!HjpU*yeXry3~{s:FXI O5Y[Y!}S˪.7bd|n]671. tn/w/+[t6}PsںsL. J;̊iN $AI)t2 Lmx:(}\-i*xQCJuWl'QyI@ھ m2DBAR4 w¢naQ`ԲɁ W=0#xBdT/.3-F>bYL%׭˓KK 6HhfPQ=h)GBms]_Ԡ'CZѨys v@c])h7Jهic?FS.NP$ e&\Ӏ+I "'%QÕ@c![paAV.9Hd<ӮHVX*%A{Yr Aբ pxSL9":3U5U NC(p%u@;[d`4)]t#9M4W=P5*f̰lk<_X-C wT%Ժ}B% Y,] A̠&oʰŨ; \lc`|,bUvPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!R%theme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK] t/t/ DDDG v{hk 6"Y$O&O(6+3v33C6t7#&)-157:@BFILQTZ\^`ac> k N<b":Cjm D!i!3#M#-$X$$9%&''('8'Q(}.a34r7t7 !"$%'(*+,./0234689;<=>?ACDEGHJKMNOPRSUVWXY[]_bd t/X$?AG!8  @2(  D   "?b  # 3"? D   "?B S  ?/@lt/x)tb)?6t"t!$!' (*++!+X+Z+[+]+^+`+a+c+d+n+x+|++++r/u/X+Z+[+]+^+`+a+c+d+++r/u/''~~noppCC*+,,99::[ !!!M!M!))*****R+X+X+Z+[+[+]+^+`+a+c+d+g+++q/u/''~~noppCC*+,,99::[ !!!M!M!))*****R+X+X+Z+[+[+]+^+`+a+c+d+g+++++++++},~,,,o/p/p/q/q/u/4 I^ >r#*Fn:_rzORUW#j]7% rt' nI*T6|@xhj@nqZ(L"hp)&x  hh^h`OJQJo( hh^h`OJQJo(@#^`56CJOJQJ\]^JaJo(. @^`OJQJ^Jo(.h^h`o(h^h`o(.0^`0o(..0^`0o(... 8^8`o( .... 8^8`o( ..... `^``o( ...... `^``o(....... ^`o(........^`OJQJ^Jo(^`OJQJ^Jo(opp^p`OJQJ^Jo(@ @ ^@ `OJQJ^Jo(^`OJQJ^Jo(o^`OJQJ^Jo(^`OJQJ^Jo(^`OJQJ^Jo(oPP^P`OJQJ^Jo( hh^h`OJQJo(^`OJQJo(hHhh^h`OJQJo(hH^`OJQJ^Jo(hHop^p`OJQJo(hH@ ^@ `OJQJo(hH^`OJQJ^Jo(hHo^`OJQJo(hH^`OJQJo(hH^`OJQJ^Jo(hHoP^P`OJQJo(hHh^`OJQJo(hHh^`OJQJ^Jo(hHohpp^p`OJQJo(hHh@ @ ^@ `OJQJo(hHh^`OJQJ^Jo(hHoh^`OJQJo(hHh^`OJQJo(hHh^`OJQJ^Jo(hHohPP^P`OJQJo(hHh^h`o(h^h`o(.0^`0o(..0^`0o(... 8^8`o( .... 8^8`o( ..... `^``o( ...... `^``o(....... ^`o(........80^8`0o(() ^`hH. pL^p`LhH. @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PL^P`LhH.^`OJQJ^Jo(^`OJQJ^Jo(opp^p`OJQJ^Jo(@ @ ^@ `OJQJ^Jo(^`OJQJ^Jo(o^`OJQJ^Jo(^`OJQJ^Jo(^`OJQJ^Jo(oPP^P`OJQJ^Jo( hh^h`OJQJo(>rn:_hUW#qZ(Lj@OI^j]7%4&x@rt'nI*`7p        n7        p=        t:        `7p        , h  %%%%%%%%%%%%%%%%%% %!%"%#%$%%,,&%'%i( 8^3FJ|O6&6([uX-g1^fhl,1P2<HM&`+0l0:MzXc_lm4:_G?JWpyK}XB;<\hh kpR c0ZKcselW"&,28G>AaBCyJ|70=FASaimjoA # & 04 or ;Q&il+oPRYbPa*aiNoLvVx%5%6S^^ )+b8<BVbPrPv*AJ = )+4:JQY`5U:dJ.OR7j[@# <QMr0\bt} u%),=HMisr  1u3dCDKRa k- 5@C[]z:;6RR*TU_iJ ) + w/ >? !!Q!!{;!}F!kR!|!!\"R""$"&"o?"d@"B""J"?Z"~"-#1#7#7Z#]#u#{#$$$ $!)$)$'5$z$t~$v~$%%M%4%-%M%Y%g%&1&&o*&&7&7&A&W&G]&e&op&-x&{&}&'O('!)'8'U'e'2~'j((eL()^(^(n ))90)1)C6)79)?)A)UJ)Wr) ** #*"$*4*t<*L*X*\*$q*^w*w*a^+m+,N,%-s:-J[-\-r-/(.U.iv.~.s/#/+/I9/B/1a/o/C001<0@0hA0N0}x0 1/!1D1oE1Q1U1l[1wl1Ot1222=2$2M:2qF2a2?u2'313,3=93)T3OY3%[3bp3 4I4L4e4Q 5w 55I5m5C2686?6O6a6t6y6 7*7+7D7G7HY7[78'8MD8D8xl8 89(9>9jj9om9w9N : :::1:zS:_:o: w:k; ; ;8;K$;N;xj;v;x;};$~;:<#<&/<E<LN<cQ<j<3l<N.= D=a=b=z=>>%> 0>K>[N>o>>?%?4?Y?_??d?u?0y?@@:4@w@/ AAlAuAALBLBSB:%BoBqB9uB~BB"Cb*CaDC&ECICbCiCvC1D9D;D;D=D?DcD,(E,E-EH7E(|EPF6FR?F?xF-G|XGG H} H H;H` H+H/HHHLHWH[H*qH!{HIII>IBIPIRIC^IlI{Ix~IVJ/Jl>J0PJUJ\JdbJiJ}JKKK`K6KL:KAKnK?L(L:L?LCTLULXL|LMMOM6WMCnMwM{MNNN!N>"N$N-N0NPIN{NOO'OKHO%iO)POPM P P P*Pw^PFcPjPqPrPQ$Q9QpIpOKpjcp#qS%qBqZqF^qHyqqrTrurK:rYQrqrzr sVs:+s-sXst&t-t5t:tUtht(u:1u3u5u`>uUu`uv3vf5vDKvLvOvw)w_dwqqwqwuwwJx x"x$x.Gx]xshxAy(ykyvyz z9.zQ9zBzDzZz]z^z^bzizcyzJ{J{Q{{T{[{i{n{~{||_R|i|}=}Z}s}zt}u}T}}I~~r~w~[ +S$$3*ECIp'/LVbXoxo%3N6R]^_ FMv_}(a+<g| +k-`1N.T("09"?E7HNi'?K Psbvd ZsNf<4^ce g-kf@Ik>{}/F&|0mM25BW1uqx*yf~S4 9e:Y\l:w{K pea:<;RjV K)1Q}\\1@6D$\wCa K>MWu)}'12;E^x*+G:?)iyT *N~jr{}NE$[|~"_'DR_Tp lY,M`j&pq|)lN?h[ajs"&CDIV :0,K9DT$,F<yR{oM*KeLNkymt^gh4SG1BpXX9;CKjo./2:@(ilw=_{`'i"3WT=h7+} t')Ni)MX_+4;w'$&,,12<EGIR[`|Q <_Q,O.]2cYl7>%3BN`d|H`~zw>8_V4= R\r1UVa_Sy>*$1kAE?pst'oi{z!3w4m9E[V_rg `@H]gtyz!7:I]{j%0[6Krw@&e*]1^5GsuuM~{[6@H[bx=Y.`>F+NDy7z|?EY[:iXDV,5XF{ ?^RYjz{a~ 4=P8Xlj!C+]0CLSs6&Y*C0Mdpz&7 &HL`b5MTs{!}p~)y3|:amf6 5"8B\aur  (O$#3#Li&rls iDx 1FBDq`mj*$*\3_v.4\45YEW]hW)@UL@fjmw-/1jYlpI/PSW_hZ.6l6w{&'4;B_F X>_qs C%__iu~'8>>YBpQ$z>ocmwx- /7<%=ku$Y7#:::RitPVSX}}]FMlS^'fK.#%/@D FMdteUf|S>I N!M55<HRZp)$&0mTW6W`m~d_ dauby3:`+s$5.8mYefjll%ugi;w7x z&*3 TV`Pj"ksHwR !$H-9%D}q"NOOTrty58:>EByX[d(y=vcd'gp!/k11khl p//L5VQ@1@AbZgy(O0Zu."9BSWknt 5KWBl*vz{z +FK[qsu5nt )(>ApGa`em | smz~;'41Dc$7%5Hn[ bbd l'0mPjb|lu'w, 48my  J(Z]^;hj"/gu%3j8B=GSgF+2;BCW[mt|2e N8Ti\ zx-8<k@GNTQ^y&Upu }Ou'5.25J;[I`LV`hq F|tu{)^$y6EXxX+Z+@   r)t/@Unknown G*Ax Times New Roman5Symbol3. *Cx Arial7. [ @Verdana7.@Calibri5. .[`)Tahoma?= *Cx Courier New;WingdingsA$BCambria Math"h *gmR3Ggx$Nx$NndxrB+B+ 3QP?-t2!xx GMO Risk Assessment Robin Butler David NorwoodD         Oh+'0  $0 P \ h tGMO Risk AssessmentRobin Butler Normal.dotmDavid Norwood6Microsoft Office Word@ @(J@OG`@v [x$՜.+,D՜.+,@ hp|  NB+ GMO Risk Assessment Title 8@ _PID_HLINKSAp&mailto:d.norwood@qub.ac.uk  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdeghijklmnopqrsuvwxyz{|}~Root Entry F [Data f1Tablet4`WordDocumentFSummaryInformation(DocumentSummaryInformation8CompObjr  F Microsoft Word 97-2003 Document MSWordDocWord.Document.89q